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Glucotrol is not for treating type 1 diabetes.
Important Information You should not use Glucotrol if you have diabetic ketoacidosis call your doctor for treatment. Before Glucotrol canada Glucotrol, tell your doctor if you have kidney or liver disease, Glucotrol canada diarrhea or a blockage in your intestines, glucosephosphate dehydrogenase deficiency G6PDa disorder of your pituitary or adrenal glands, a history of heart disease, Glucotrol Canada, or if you are malnourished.
Before taking this medicine You should not use Glucotrol if you are allergic to glipizide, or if you have diabetic ketoacidosis call your doctor for treatment. Tell your doctor if you have Glucotrol canada had: Follow your doctor’s instructions about using Glucotrol if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.
You should not take Glucotrol during the last 2 weeks of pregnancy.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
How should I take Glucotrol? Take Glucotrol Glucotrol canada as prescribed by your doctor. Follow all directions on your prescription label.
Your doctor may Glucotrol canada change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take the regular tablet 30 minutes before your first meal of the day. Take the Glucotrol XL extended-release tablet with your Glucotrol canada meal of the day. Swallow the tablet whole and do not crush, chew, or break it.
In post-marketing reports, hemolytic anemia has also been reported in patients who did not have known G6PD deficiency.
Laboratory Tests Blood and urine glucose should be monitored periodically. Measurement of glycosylated hemoglobin may be useful. Carcinogenesis, Mutagenesis, Impairment Of Fertility A twenty month study in rats and an eighteen month study in mice at doses up to 75 times the Glucotrol canada human dose revealed no evidence of drug-related carcinogenicity. Bacterial and in vivo mutagenicity tests were uniformly negative. Studies in rats of both sexes at doses up to 75 times the human dose showed no effects on fertility.
This fetotoxicity has been Glucotrol canada noted with other sulfonylureas, such as tolbutamide and tolazamide, Glucotrol Canada. In studies in rats and rabbits, no teratogenic effects were found. There are no adequate and well controlled studies in pregnant women. Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible.
Nonteratogenic Effects Prolonged severe hypoglycemia 4 to 10 days has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported Glucotrol canada frequently with the use of agents with prolonged half-lives.
Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother, Glucotrol Canada. If the drug is discontinued and if diet Glucotrol canada is Glucotrol canada for controlling blood glucose, insulin therapy should be considered. Pediatric Use Safety and effectiveness in children have not been established. Geriatric Use A determination has not been made whether controlled clinical studies of GLUCOTROL included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
Other reported clinical experience has not identified differences in responses between the Glucotrol canada and younger patients.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy, Glucotrol Canada.
Close monitoring should continue until the physician is assured that the patient is out of danger, Glucotrol Canada. Severe hypoglycemic reactions with coma, seizureor other neurological impairment occur Glucotrol canada, but constitute medical emergencies requiring immediate hospitalization.
Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Known hypersensitivity to the drug. Type 1 diabetes mellitusdiabetic ketoacidosisGlucotrol Canada, with or without coma. This condition should be treated with insulin. In humans, GLUCOTROL appears to lower the blood glucose Glucotrol canada by stimulating the release of insulin from the pancreas, Glucotrol Canada, an effect dependent upon functioning beta cells in the pancreatic islets.
Fasting insulin levels are not elevated even on long-term GLUCOTROL administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment.
The insulinotropic response to a meal occurs within 30 minutes Glucotrol canada an oral dose of GLUCOTROL in diabetic patients, but elevated insulin levels do not persist beyond the time of the meal challenge. Extrapancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs.
glipizide (Glipizide XL, Glucotrol)
Blood sugar control persists in some patients for up to 24 hours after a single dose of GLUCOTROL, Glucotrol canada though plasma levels have declined to a small fraction of peak levels by that time see Pharmacokinetics below. Peak plasma concentrations occur 1—3 hours after a single oral dose.
The half-life of elimination ranges from 2—4 hours in normal subjects, whether given intravenously or orally. The metabolic and excretory patterns are similar with the two routes of administration, indicating that first-pass metabolism is not significant. Total absorption and disposition of an Glucotrol canada dose was unaffected by food in Glucotrol canada volunteers, Glucotrol Canada, but absorption was delayed by about 40 minutes.
In another study, however, very small amounts of radioactivity were detected in the fetuses of rats given labelled drug. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. The risks of hypoglycemiaits symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members.
Primary and secondary failure should also be explained. Physician Counseling Information For Patients In initiating treatment for type 2 diabetesdiet should be emphasized as the primary form of treatment.